Annotation Overview for fig|208964.1.peg.2001 in Pseudomonas aeruginosa PAO1:
3-ketoacyl-CoA thiolase (EC 2.3.1.16) @ Acetyl-CoA acetyltransferase (EC 2.3.1.9)

current assignment	This feature plays multiple roles which are implemented by the same domain with a broad specificity. The roles are: 3-ketoacyl-CoA thiolase (EC 2.3.1.16) EC Number 2.3.1.16 Acetyl-CoA acetyltransferase (EC 2.3.1.9) EC Number 2.3.1.9 3-ketoacyl-CoA thiolase (EC 2.3.1.16) @ Acetyl-CoA acetyltransferase (EC 2.3.1.9)
taxonomy id	208964	contig	208964.1:NC_002516 (6,264,404bp)
internal links	genome browser | feature evidence | sequence	ACH Annotation Clearinghouse (ACH) The Annotation Clearinghouse offers a mapping of genes which are identical in sequence except for the start region (due to differences in start calling). [?]	show essentially identical genes
annotation history		run tool	Psi-BlastTMpredTMHMMGram negative PSORTGram negative SignalPGram positive PSORTGram positive SignalPLipoPInterProScanRadarPPSearchGram negative CELLOGram positive CELLOProDomPDB
FigFam	FIG000004

Annotation History (history of similar genes)

Date	Annotator	Annotation
10/18/2004	OlgaZ	Set FIG function to Acetyl-CoA acetyltransferase (EC 2.3.1.9)
8/8/2005	OlgaZ	Set FIG function to 3-ketoacyl-CoA thiolase (EC 2.3.1.16); Acetyl-CoA acetyltransferase (EC 2.3.1.9)
6/7/2006	OlgaV	Set FIG function to 3-ketoacyl-CoA thiolase (EC 2.3.1.16); Acetyl-CoA acetyltransferase (EC 2.3.1.9)
6/26/2006	OlgaV	Set FIG function to 3-ketoacyl-CoA thiolase (EC 2.3.1.16); Acetyl-CoA acetyltransferase (EC 2.3.1.9)
5/28/2008	OlgaZ	Set function to Acetyl-CoA acetyltransferase (EC 2.3.1.9)
11/9/2008	OlgaV	Set FIG function to 3-ketoacyl-CoA thiolase (EC 2.3.1.16) @ Acetyl-CoA acetyltransferase (EC 2.3.1.9)

The encoded protein plays multiple roles which are implemented by the same domain with a broad specificity. The roles are "3-ketoacyl-CoA thiolase (EC 2.3.1.16)" and "Acetyl-CoA acetyltransferase (EC 2.3.1.9)". The protein occurs in 8 subsystems: "Acetyl-CoA fermentation to Butyrate", "Butanol Biosynthesis", "Glyoxylate bypass", "Isoleucine degradation", "Isoprenoid Biosynthesis", "Polyhydroxybutyrate metabolism", "Serine-glyoxylate cycle", and "n-Phenylalkanoic acid degradation". In "Polyhydroxybutyrate metabolism", it occurs in close proximity on the chromosome with 5 other genes from the same subsystem. In "Serine-glyoxylate cycle", it occurs in close proximity on the chromosome with 2 other genes from the same subsystem. The function of genes having the same functional roles have been described in Homo sapiens (15733928, 7911016) and Chromobacterium violaceum (10427049). These are homologous proteins which implement the same function.

The chromosomal region of the focus gene (top) is compared with four similar organisms. The graphic is centered on the focus gene, which is red and numbered 1. Sets of genes with similar sequence are grouped with the same number and color. Genes whose relative position is conserved in at least four other species are functionally coupled and share gray background boxes. The size of the region and the number of genomes may be reset. Click on any arrow in the display to refocus the comparison on that gene. The focus gene always points to the right, even if it is located on the minus strand.